Medication comparison
Tirzepatide vs Semaglutide: Which Loses More Weight?
Tirzepatide and semaglutide are the two leading injectable weight loss medications. Tirzepatide is a newer dual-action drug; here is how the two stack up.
| Consideration | Tirzepatide | Semaglutide |
|---|---|---|
| Brand names | Zepbound, Mounjaro | Wegovy, Ozempic |
| Mechanism | GLP-1 + GIP (dual) | GLP-1 (single) |
| Avg. weight loss* | ~21% body weight | ~15% body weight |
| Max dose | 15 mg weekly | 2.4 mg weekly |
| Dosing | Once weekly | Once weekly |
| Common side effects | Nausea, GI upset | Nausea, GI upset |
| Typical cash price | $1,000+/mo brand | $1,000+/mo brand |
The verdict
In head-to-head trials, tirzepatide produced greater average weight loss than semaglutide, likely thanks to its dual GLP-1/GIP action. Semaglutide has a longer real-world track record. Both are highly effective — the right choice depends on tolerance, cost and clinician guidance.
*Weight-loss figures are from published clinical trials; individual results vary. This is educational information, not medical advice.
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