Medication comparison
Wegovy vs Ozempic: What's the Difference?
Wegovy and Ozempic are both semaglutide — the same active ingredient — but they are approved for different uses and dosed differently. Here is how they compare for weight loss.
| Consideration | Wegovy | Ozempic |
|---|---|---|
| Active ingredient | Semaglutide | Semaglutide |
| FDA-approved for | Chronic weight management | Type 2 diabetes |
| Max dose | 2.4 mg weekly | 2.0 mg weekly |
| Avg. weight loss* | ~15% body weight | ~12–14% body weight |
| Use for weight loss | On-label | Off-label |
| Typical cash price | $1,300+/mo | $1,000+/mo |
| Insurance coverage | Sometimes (weight) | Often (diabetes) |
The verdict
For weight loss specifically, Wegovy is the on-label choice with the higher approved dose and strongest trial data. Ozempic is frequently prescribed off-label and may be easier to get covered if you also have type 2 diabetes. A clinician can advise which fits your situation.
*Weight-loss figures are from published clinical trials; individual results vary. This is educational information, not medical advice.
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